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  • SSR 149415
SSR 149415的可视化放大

SSR 149415

强效选择性加压素 V1B 拮抗剂

原价
¥4600-19212
价格
3680-15370
SSR 149415的二维码

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  • 库存: 现货
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  • 货号: ajcx27446
  • CAS: 439687-69-1
  • 别名:
  • 分子式: C30H32ClN3O8S
  • 分子量: 630.11
  • 纯度: >98%
  • 溶解度: 63.01mg/ml in DMSO; 63.01mg/ml in ethanol
  • 储存: Store at -20°C
  • 库存: 现货

Background

Potent and selective vasopressin V1B antagonist (Ki values are 3.7 and 1.3 nM for native and recombinant rat V1b receptors, respectively). Displays >70-fold selectively for rat V1B over V1A, V2 oxytoxin and a range of other receptors and ion channels. Inhibits AVP-induced glucagon release in In-R1-G9 α-pancreatic cells in vitro. Inhibits stress-induced ACTH release and exhibits anxiolytic-like effects in anxiety models. Orally bioavailable.



Serradeil-Le Gal et al (2005) An overview of SSR149415, a selective nonpeptide vasopressin V1b receptor antagonist for the treatment of stress-related disorders. CNS Drug Rev. 11 53 PMID:15867952

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