安捷凯在线客服
- 客服:
- 电话: 13061953619
- 微信:
Squarunkin A hydrochloride 是一种有效的、选择性的 UNC119-cargo 相互作用抑制剂(抑制 UNC119A-myristoylated Src N-末端肽相互作用的 IC50 为 10 nM)。 Squarunkin A hydrochloride 干扰细胞中 Src 激酶的激活。
Potent inhibitor of UNC119 chaperone protein-cargo interaction (IC50 = 10 nM for inhibition of UNC119A - myristoylated Src N-terminal peptide interaction). Disrupts activation of Src kinase in vitro.
Mejuch et al (2017) Small-molecule inhibition of the UNC119-cargo interaction. Angew.Chem.Int.Ed. 56 6181 PMID:28471079
动态评分
0.0