AC 253 是一种胰淀素拮抗剂，可抑制 125I-肾上腺髓质素结合，IC50 为 25 nM。
Amylin (AMY3) receptor antagonist. Inhibits andrenomedulin-stimulated cAMP production in vitro. Protects against oligomeric Aβ-induced increase in intracellular Ca2+, activation of PKA, MAPK, Akt and cFOS and cell death in neuronal cell culture. Blocks electrophysiological effects of Aβ in vitro. Cyclic AC 253 (Cat.No. 6550) also available.
Coppock et al (1999) Rat-2 fibroblasts express specific adrenomedullin receptors, but not calcitonin-gene-related-peptide receptors, which mediate increased intracellular cAMP and inhibit mitogen-activated protein kinase activity. Biochem.J. 338 15 PMID:9931292 |Jhamandas et al (2011) Actions of β-amyloid protein on human neurons are expressed through the amylin receptor. Am.J.Pathol. 178 140 PMID:21224052 |Fu et al (2012) Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways. J,Biol.Chem. 287 18820 PMID:22500019
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