A monoterpenoid with diverse biological activities
Safranal is a monoterpenoid that has been found in C. sativus and has diverse biological activities, including microtubule polymerization inhibitory, cancer cell growth inhibitory, and antioxidant properties.1,2,3,4 It decreases microtubule polymerization in a cell-free assay (IC50 = 72.19 ?M) and inhibits the growth of HeLa cells (IC50 = 95 ?M).1,2 Safranal (145.5, 363.75, and 727.5 mg/kg) reduces the levels of thiobarbituric acid reactive substances (TBARS) and malondialdehyde (MDA) in the hippocampus in a rat model of global cerebral ischemia.3 It also reduces convulsions induced by pentylenetetrazole in mice.4
1.Naghshineh, A., Dadras, A., Ghalandari, B., et al.Safranal as a novel anti-tubulin binding agent with potential use in cancer therapy: An in vitro studyChem. Biol. Interact.238151-160(2015) 2.Cheriyamundath, S., Choudhary, S., and Lopus, M.Safranal inhibits HeLa cell viability by perturbing the reassembly potential of microtubulesPhytother. Res.32(1)170-173(2018) 3.Hosseinzadeh, H., and Sadeghnia, H.R.Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampusJ. Pharm. Pharm. Sci.8(3)394-399(2005) 4.Hosseinzadeh, H., and Talebzadeh, F.Anticonvulsant evaluation of safranal and crocin from Crocus sativus in miceFitoterapia76(7-8)722-724(2005)
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