现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • Batabulin sodium
Batabulin sodium的可视化放大

Batabulin sodium

An inhibitor of tubulin polymerization

原价
¥1962-7337
价格
1570-5870
Batabulin sodium的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajcx30232
  • CAS: 195533-98-3
  • 别名: T138067 sodium
  • 分子式: C13H6F6NNaO3S
  • 分子量: 393.24
  • 纯度: >98%
  • 溶解度: DMSO: 125 mg/mL (317.87 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

Batabulin is an inhibitor of tubulin polymerization.1 It covalently binds to cysteine 239 (Cys239) of the β1, β2, and β4 tubulin isotypes and inhibits polymerization of bovine brain tubulin (IC50 = 2 ?M) in cell-free assays. Batabulin (30, 100, and 300 nM) induces cytoskeletal collapse and cell cycle arrest at the G2/M phase in MCF-7 breast cancer cells. It is cytotoxic against a panel of drug-sensitive and -resistant cancer cell lines (IC50s = 11-165 nM). Batabulin (40 mg/kg) reduces tumor volume in CCRF CEM lymphoblastic leukemia and CEM/VBL100 multidrug-resistant lymphoblastic leukemia mouse xenograft models.


1.Shan, B., Medina, J.C., Santha, E., et al.Selective, covalent modification of β-tubulin residue Cys-239 by T138067, an antitumor agent with in vivo efficacy against multidrug-resistant tumorsProc. Natl. Acad. Sci. USA96(10)5686-5691(1999)

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服