Phenidone (1-phenyl-3-pyrazolidinone), a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer.
Phenidone (1-phenyl-3-pyrazolidinone), a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer.
Phenidone has provided neuroprotection in various experimental paradigms of neurodegeneration including kainate-induced excitotoxicity, ischemia, microglia-mediated neurotoxicity, and autoimmune encephalomyelitis. However, the neuroprotective effect of the compound appeared to be associated not only with inhibition of COX and LOX activities but also with its direct antioxidant property. Microglia-related neurotoxicity is believed to be partially mediated by oxidative/nitrosative stress[1].
[1] Li Z, et al. Neurosci Lett. 2008, 445(1):1-6.
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