11-oxo Etiocholanolone 是皮质醇和 11-酮睾酮的代谢产物。由皮质醇经可的松和四氢可的酮中间体形成，由11-酮睾酮经5β-11-酮二氢睾酮和3α-11-酮基胆二醇中间体形成.?妊娠期间 11-氧代胆烷醇酮的尿液水平升高，并且在子宫平滑肌瘤患者中升高。11-氧代胆烷醇酮的粪便水平已被用作家畜和散养反刍动物压力的标志物。
11-oxo Etiocholanolone is a metabolite of cortisol and 11-keto testosterone.1,2 It is formed from cortisol via cortisone and tetrahydrocortistone intermediates, and it is formed from 11-keto testosterone via 5β-11-keto dihydrotestosterone and 3α-11-keto etiocholanediol intermediates. Urinary levels of 11-oxo etiocholanolone increase during pregnancy and are elevated in patients with uterine leiomyomas.3,4 Fecal levels of 11-oxo etiocholanolone have been used as a marker of stress in domestic livestock and free-range ruminants.5
1.Schiffer, L., Barnard, L., Baranowski, E.S., et al.Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive reviewJ. Steroid Biochem. Mol. Biol.194105439(2019) 2.Barnard, L., Nikolaou, N., Louw, C., et al.The A-ring reduction of 11-ketotestosterone is efficiently catalysed by AKR1D1 and SRD5A2 but not SRD5A1J. Steroid Biochem. Mol. Biol.202105724(2020) 3.Birke, G., Gemzell, C.A., Plantin, L.O., et al.Plasma levels of 17-hydroxycorticosteroids and urinary excretion pattern of keto-steroids in normal pregnancyActa Endocrinol. (Copenh.)27(4)389-402(1958) 4.Jung, B.H., Bai, S.W., and Chung, B.C.Endogenous urinary steroids in premenopausal women with uterine leiomyomasInt. J. Gynaecol. Obstet.84(1)55-60(2004) 5.Molina-García, L., Pérez, J.M., Sarasa, M., et al.HPLC-QTOF method for quantifying 11-ketoetiocholanolone, a cortisol metabolite, in ruminants' feces: Optimization and validationEcol. Evol.8(18)9218-9228(2018)
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