A synthetic progestogen
Melengestrol acetate is a synthetic progestogen and derivative of progesterone.1 It binds to progesterone receptors in rhesus monkey myometrial cytosolic preparations with high affinity relative to progesterone. Melengestrol acetate (0.1 mg/animal per day) suppresses estrus in rats.2 It reduces tumor growth in androgen-dependent and -independent prostate tumors in rats when administered at a dose of 10 mg/kg.3 Formulations containing melengestrol acetate have been used to increase weight gain, improve feed efficiency, and suppress estrus in heifer cattle.
1.Illingworth, D.V., Elsner, C., De La Cruz, K.D.G., et al.A specific progesterone receptor of myometrial cytosol from the rhesus monkeyJ. Steroid Biochem.8(2)157-160(1977) 2.Chakraborty, P.K., Kliewer, R.H., and Hisaw Jr., F.L.Effect of melengestrol acetate on growth and reproduction in ratsJ. Dairy Sci.61(12)1778-1781(1978) 3.Padilla, G.M., Yacullo, R.C., Padilla, J.J., et al.Melengestrol acetate and megestrol acetate are prostatic tumor inhibiting agentsBiochem. Cell Biol.68(10)1181-1188(1990)
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