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Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with a Ki of 17 nM in the FP assay. Sulfopin blocks Myc-driven tumor initiation and growth in vivo.
Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with a Ki of 17 nM in the FP assay. Sulfopin blocks Myc-driven tumor initiation and growth in vivo.
Sulfopin is a highly selective covalent inhibitor of Pin1 (peptidyl-prolyl isomerase) due to target engagement and phenocopies Pin1 genetic knockout, with a Ki of 17 nM in Fluorescence polarization (FP) test.[1]
Sulfopin induces downregulation of c-Myc target genes, and reduces tumor progression and confers survival benefit in vivo.[1]
[1] Christian Dubiella, et al. Nat Chem Biol. 2021 Sep;17(9):954-963.
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