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  • Sulfopin
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Sulfopin

Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with a Ki of 17 nM in the FP assay. Sulfopin blocks Myc-driven tumor initiation and growth in vivo.

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¥1037-8687
价格
830-6950
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  • 货号: ajcx33072
  • CAS: 2451481-08-4
  • 别名: PIN1-3
  • 分子式: C11H20ClNO3S
  • 分子量: 281.8
  • 纯度: >98%
  • 溶解度: DMSO : 100 mg/mL (354.86 mM; Need ultrasonic)
  • 储存: Store at -20°C
  • 库存: 现货

Background

Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with a Ki of 17 nM in the FP assay. Sulfopin blocks Myc-driven tumor initiation and growth in vivo.


Sulfopin is a highly selective covalent inhibitor of Pin1 (peptidyl-prolyl isomerase) due to target engagement and phenocopies Pin1 genetic knockout, with a Ki of 17 nM in Fluorescence polarization (FP) test.[1]


Sulfopin induces downregulation of c-Myc target genes, and reduces tumor progression and confers survival benefit in vivo.[1]


[1] Christian Dubiella, et al. Nat Chem Biol. 2021 Sep;17(9):954-963.

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