OATD-01

An inhibitor of CHIT1 and CHIA

原价

￥1625-13350

价格

￥ 1300-10680

所有产品仅用于科学研究，我们不为任何个人用途提供产品和服务

询价有惊喜，量大更优惠

库存: 现货

可选包装 >>>

首页

产品引用

货号: ajcx33106
CAS: 2088453-21-6
别名:
分子式: C19H27ClN6O
分子量: 390.91
纯度: >98%
溶解度: DMSO : 100 mg/mL (255.81 mM; Need ultrasonic)
储存: Store at -20°C, protect from light, stored under nitrogen
库存: 现货

Background

OATD-01 is an inhibitor of chitotriosidase 1 (CHIT1) and acidic mammalian chitinase (CHIA), also known as AMCase (IC₅₀s = 23 and 9 nM, respectively).¹ It is selective for CHIT1 and CHIA over a panel of 98 enzymes at 10 ?M. OATD-01 (30 and 100 mg/kg) reduces the degree of lung fibrosis and plasma chitinolytic activity in a mouse model of pulmonary fibrosis induced by bleomycin .

1.Koralweski, R., Dymek, B., Mazur, M., et al.Discovery of OATD-01, a first-in-class chitinase inhibitor as potential new therapeutics for idiopathic pulmonary fibrosisJ. Med. Chem.63(24)15527-15540(2020)

动态评分

0.0

没有评分数据

没有评价数据

信号通路

生命科学

有机化学

无机化学

材料科学

OATD-01

OATD-01详情

Background