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YKL-5-124

YKL-5-124 is a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for inhibiting CDK7/Mat1/CycH, CDK2 and CDK9 respectively. It displays biochemical and cellular selectivity for CDK7 over CDK12/13.

原价

￥2775-7500

价格

￥ 2220-6000

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产品引用

货号: ajcx33438
CAS: 1957203-01-8
别名:
分子式: C28H33N7O3
分子量: 515.61
纯度: >98%
溶解度: DMSO : 250 mg/mL (484.86 mM; Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

YKL-5-124 is a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for inhibiting CDK7/Mat1/CycH, CDK2 and CDK9 respectively. It displays biochemical and cellular selectivity for CDK7 over CDK12/13.

[1] Calla M Olson, et al. Cell Chem Biol. 2019 Jun 20;26(6):792-803.e10.

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