TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group.
TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group.
Treatment with TD-165 causes a concentration-dependent decrease in the level of CRBN proteins by Western blot analysis.[1]
TD-165 do not affect CRBN levels in the spleen, peripheral blood mononuclear cells (PBMCs), or liver of mice by immunoblotting, which might be attributable to the high plasma protein binding of TD-165. [1]
[1] Kim K, et al. Sci Rep. 2019 Dec 23;9(1):19654.
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