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A DOT1L inhibitor
DOT1L-IN-4 is an inhibitor of the non-SET domain-containing methyltransferase DOT1L (IC50 = 0.11 nM).1 It is selective for DOT1L over a panel of 11 additional histone methyltransferases at 5 ?M.
1.Stauffer, F., Weiss, A., Scheufler, C., et al.New potent DOT1L inhibitors for in vivo evaluation in mouseACS Med. Chem. Lett.10(12)1655-1660(2019)
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