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Sephin-1 (NSC-65390) is a selective inhibitor of a holophosphatase, a small molecule that safely and selectively inhibits a regulatory subunit of protein phosphatase 1 in vivo. Sephin-1 (NSC-65390) selectively bounds and inhibits the stress-induced PPP1R1
Sephin-1 (NSC-65390) is a selective inhibitor of a holophosphatase, a small molecule that safely and selectively inhibits a regulatory subunit of protein phosphatase 1 in vivo. Sephin-1 (NSC-65390) selectively bounds and inhibits the stress-induced PPP1R15A.
Sephin1 stimulates ATF4 synthesis in the absence of stress.[2]
[1] Indrajit Das, et al. Science. 2015 Apr 10;348(6231):239-42. [2] Bugallo R, et al. Cell Death Dis. 2020 May 26;11(5):397.
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