PFI-90 is a selective inhibitor of the histone demethylase KDM3B. PFI-90 induces apoptosis and cell differentiation resulting in delayed tumor progression in vivo.
PFI-90 is a selective inhibitor of the histone demethylase KDM3B. PFI-90 induces apoptosis and cell differentiation resulting in delayed tumor progression in vivo.
PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. In RH4 and SCMC cells, PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. [2]
PFI-90 induces apoptosis and cell differentiation resulting in delayed tumor progression in vivo. [1]
[1] Yong Yean Kim, et al. AACR Cancer Research 2021 July Volume 81, Issue 13 [2] KHAN, Javed, et al. Inhibitors of histone demethylases (pfi-63 and pfi-90) for the treatment of cancer and for the inhibition of histone demethylase in cells. WO2021101929A1.
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