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  • SCR130
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SCR130

SCR130 is a novel DNA repair inhibitor with IC50s of 14 μM in Reh cells and 2 μM in Nalm6 cells. SCR130 specifically inhibits DNA Ligase IV‐mediated joining with minimal or no effect on Ligase III and Ligase I mediated joining.

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¥612-987
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490-790
SCR130的二维码

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  • 货号: ajcx34230
  • CAS: 2377858-38-1
  • 别名:
  • 分子式: C19H13Cl2N3O2S
  • 分子量: 418.3
  • 纯度: >98%
  • 溶解度:
  • 储存: Store at -20°C
  • 库存: 现货

Background

SCR130 is a novel DNA repair inhibitor with IC50s of 14 μM in Reh cells and 2 μM in Nalm6 cells. SCR130 specifically inhibits DNA Ligase IV‐mediated joining with minimal or no effect on Ligase III and Ligase I mediated joining.


SCR130 is a new a novel inhibitor of nonhomologous end-joining (NHEJ) by leading to loss of mitochondrial membrane potential leading to cell death by activating both intrinsic and extrinsic pathways of apoptosis, showing the IC50 of 14.1 μM in Reh cells and 2.2 μM in Nalm6 cells.[1]


[1] Ujjayinee Ray, et al. Mol Carcinog. 2020 Jun;59(6):618-628.

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