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(E/Z)-GO289 potently and selectively inhibits casein kinase 2 (CK2) at an IC50 of 7 nM in vitro kinase assay.
(E/Z)-GO289 potently and selectively inhibits casein kinase 2 (CK2) at an IC50 of 7 nM in vitro kinase assay.
(E/Z)-GO289 has an effectively and selectively inhibition of casein kinase-2 (CK2), especially on CK2α and CK2α′, thus regulate the phosphorylation of clock protein. .[1]
[1] Tsuyoshi Oshima, et al. Sci Adv . 2019 Jan 23;5(1):eaau9060.
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