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(R)-PF-06256142 是 PF-06256142 的 R 型活性较差的对映异构体。PF-06256142 是一种有效的、选择性的正构 D1 receptor 激动剂,可以减少相对于多巴胺和其他含儿茶酚激动剂的受体脱敏。
(R)-PF-06256142 is the R enantiomer of PF-06256142 with low active. PF-06256142 is a potent and selective orthosteric D1 receptor agonist that can reduce receptor desensitization relative to dopamine and other catechol-containing agonists[1].
[1]. Davoren JE, et al. Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization. J Med Chem. 2018;61(24):11384-11397.
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