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  • CA77.1
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CA77.1

CA77.1 (CA) is a potent, brain-penetrant and orally active activator of chaperone-mediated autophagy (CMA) for the treament of Alzheimer's disease (AD).

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¥650-5400
价格
520-4320
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  • 货号: ajcx34596
  • CAS: 2412270-22-3
  • 别名:
  • 分子式: C16H12ClN3O
  • 分子量: 297.74
  • 纯度: >98%
  • 溶解度: DMSO : 5 mg/mL (16.79 mM; ultrasonic and warming and heat to 60°C)|Ethanol : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
  • 储存: 4°C, protect from light
  • 库存: 现货

Background

CA77.1 (CA) is a potent, brain-penetrant and orally active activator of chaperone-mediated autophagy (CMA) for the treament of Alzheimer's disease (AD).


CA77.1 activates CMA in vitro in dose- and time-dependent manner without affecting macroautophagy and when administering in vivo demonstrate brain penetrance with favorable pharmacokinetics, activation of CMA in brain of KFERQ-Dendra mice, and absence of blood or major organs toxicity after 3 months of daily treatment.[2]


[1] Mathieu Bourdenx, et al. Cell. 2021 May 13;184(10):2696-2714.e25. [2] Bourdenx M, et al. Cell. 2021 May 13;184(10):2696-2714.e25.

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