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CA77.1 (CA) is a potent, brain-penetrant and orally active activator of chaperone-mediated autophagy (CMA) for the treament of Alzheimer's disease (AD).
CA77.1 (CA) is a potent, brain-penetrant and orally active activator of chaperone-mediated autophagy (CMA) for the treament of Alzheimer's disease (AD).
CA77.1 activates CMA in vitro in dose- and time-dependent manner without affecting macroautophagy and when administering in vivo demonstrate brain penetrance with favorable pharmacokinetics, activation of CMA in brain of KFERQ-Dendra mice, and absence of blood or major organs toxicity after 3 months of daily treatment.[2]
[1] Mathieu Bourdenx, et al. Cell. 2021 May 13;184(10):2696-2714.e25. [2] Bourdenx M, et al. Cell. 2021 May 13;184(10):2696-2714.e25.
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