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Ganoderic acid F 是灵芝酸。Ganoderic acid F 通过抑制血管生成和涉及细胞增殖和/或细胞死亡,致癌作用,氧化应激,钙信号传导和内质网应激的蛋白质改变来显示抗肿瘤和抗转移活性。
Ganoderic acid F is a ganoderic acid. Ganoderic acid F exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and/or cell death, carcinogenesis, oxidative stress, calcium signaling, and endoplasmic reticulum stress[1][2].
Ganoderic acid F (48 hours) inhibits the proliferation of HeLa human cervical carcinoma cells with an IC50 value of 19.5 μM[2].
[1]. Teekachunhatean S, et al. Pharmacokinetics of ganoderic acids a and f after oral administration of ling zhi preparation in healthy male volunteers. Evid Based Complement Alternat Med. 2012;2012:780892.
[2]. Yue QX, et al. Effects of triterpenes from Ganoderma lucidum on protein expression profile of HeLa cells. Phytomedicine. 2010 Jul;17(8-9):606-13.
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