A dipeptide
Glutaurine is a dipeptide composed of L-glutamic acid and taurine that has been found in rat brain.1 It is formed from glutathione and taurine by γ-glutamyl transpeptidase. Glutaurine enhances potassium-induced release of L-glutamate and inhibits kainate-induced formation of cGMP in isolated mouse cerebral cortical slices when used at concentrations of 0.1 and 1 mM, respectively.2 It decreases plasma levels of triiodothyronine (T3) and increases plasma thyroid-stimulating hormone (TSH) levels in rats when administered at a dose of 600 ?g/kg.3 Glutaurine (50 ?g/animal, p.o.) prevents electroconvulsive shock-induced amnesia in rats.4
1.T?r?k, K., Varga, V., Somogyi, J., et al.Formation of γ-glutamyl-taurine in the rat brainNeurosci. Lett.27(2)145-149(1981) 2.Varga, V., Janáky, R., Marnela, K.-M., et al.Interactions of γ-L-glutamyltaurine with excitatory aminoacidergic neurotransmissionNeurochem. Res.19(3)243-248(1994) 3.Baskin, S.I., Bartuska, D., Thampi, N., et al.The effect of glutaurine on thyroid hormones in the ratNeuropeptides9(1)45-50(1987) 4.Balazs, M., and Telegdy, G.Effects of glutaurine treatment on electroshock-induced amnesia. Antiamnesic action of glutaurineNeuropeptides12(2)55-58(1988)
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