现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • 10074-A4
10074-A4的可视化放大

10074-A4

10074-A4 是一种 c-Myc 结合化合物,与 c-Myc370–409 结合,表现得像“蛋白质云”周围的“配体云”,具有与非结合配体截然不同的特征。具有抗癌作用

原价
¥3050-10362
价格
2440-8290
10074-A4的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajcx35952
  • CAS: 312631-87-1
  • 别名:
  • 分子式: C18H14Cl2N2O3S
  • 分子量: 409.29
  • 纯度: >98%
  • 溶解度:
  • 储存: Store at -20°C
  • 库存: 现货

Background

10074-A4 is a c-Myc inhibitor. 10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain. 10074-A4 has anticancer effects[1][2].


10074-A4 shows inhibitory activity of HL-60 cells with an IC50 of 15.1 μM[1].10074-A4 (25-50 μM; 24 hours) arrests the cell cycle at the S-phase in a dose-dependent manner in HL-60 cells. 10074-A4 inhibits the mRNA level of the c-Myc target genes, CCND2 and CDK4[1].10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain and its binding behavior could be described as a ’ligand cloud’. Even in the bound state, the structure of the c-Myc370-409 peptide remained a dynamic ensemble. The 10074-A4 ligand bound at different sites throughout the c-Myc370-409 chain with different strength[2].


[1]. Chen Yu, et al. Structure-based Inhibitor Design for the Intrinsically Disordered Protein c-Myc. Sci Rep. 2016 Mar 2;6:22298.
[2]. Fan Jin, et al. Ligand clouds around protein clouds: a scenario of ligand binding with intrinsically disordered proteins. PLoS Comput Biol. 2013;9(10):e1003249.

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服