Ruscogenin通过调节 PI3K/Akt/mTOR 信号通路，降低 MMP-2、MMP-9、uPA、VEGF 和 HIF-1α 的表达，抑制肝癌转移； Ruscogenin 通过抑制 TLR4 信号通路减轻 LPS 诱导的肺内皮细胞凋亡。
Ruscogenin suppresses HCC metastasis by reducing the expression of MMP-2, MMP-9, uPA, VEGF and HIF-1α via regulating the PI3K/Akt/mTOR signaling pathway[1]. And Ruscogenin alleviates LPS-induced pulmonary endothelial cell apoptosis by su
[1]. Hua H, Zhu Y, Song YH. Ruscogenin suppressed the hepatocellular carcinoma metastasis via PI3K/Akt/mTOR signaling pathway. Biomed Pharmacother. 2018;101:115-122.
[2]. Wu Y, Wang Y, Gong S, et al. Ruscogenin alleviates LPS-induced pulmonary endothelial cell apoptosis by suppressing TLR4 signaling. Biomed Pharmacother. 2020;125:109868.
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