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  • Nepafenac
Nepafenac的可视化放大

Nepafenac

A prodrug from of amfenac

原价
¥462-1575
价格
370-1260
Nepafenac的二维码

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  • 货号: ajci11516
  • CAS: 78281-72-8
  • 别名: 奈帕芬胺; AHR 9434; AL 6515
  • 分子式: C15H14N2O2
  • 分子量: 254.28
  • 纯度: >98%
  • 溶解度: ≥ 9.95mg/mL in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

Nepafenac is a non-steroidal anti-inflammatory drug (NSAID). The IC50 values of nepafenac for (cyclooxygenase-1) COX-1 and COX-2 are 250 nM and 150 nM, respectively [1].


Nepafenac showed to significantly decrease the retinal levels of PGE2 in LPS-induced rats when administrated topically. However, nepafenac has revealed no significant effect on BRB permeability in LPS-induced rat model [1].


Nepafenac significantly reduced proliferation rate of human uveal melanoma cell lines including SP6.5, 92.1, OCM-1, MKT-BR and of human transformed uveal melanocyte cell line UW-1. Compared to rofecoxib, nepafenac might reveal a better systemic safety profile [2].

参考文献:
[1] Bucolo C1,?Marrazzo G,?Platania CB,?Romano GL,?Drago F,?Salomone S. Effects of topical indomethacin, bromfenac and nepafenac on lipopolysaccharide-induced ocular inflammation. J Pharm Pharmacol.?2014 Jul;66(7):954-60.
[2] Marshall JC1,?Caissie AL,?Cruess SR,?Cools-Lartigue J,?Burnier MN Jr. The effects of a cyclooxygenase-2 (COX-2) expression and inhibition on human uveal melanoma cell proliferation and macrophage nitric oxide production. J Carcinog.?2007 Nov 27;6:17.

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