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  • GBLD 345
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GBLD 345

GABAA receptor agonist

原价
¥1437-5650
价格
1150-4520
GBLD 345的二维码

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  • 货号: ajci17232
  • CAS: 122479-08-7
  • 别名:
  • 分子式: C21H21N5O2
  • 分子量: 375.43
  • 纯度: >98%
  • 溶解度: Soluble in ethanol or DMSO
  • 储存: Store at RT
  • 库存: 现货

Background

GBLD 345 is a potent agonist of benzodiazepine receptor.


Benzodiazepine receptor is an allosteric modulatory site on GABAA receptor [1]. The GABAA receptor is a ligand-gated ion channel and activated by γ-aminobutyric acid (GABA). The GABAA receptor selectively permits Cl- through its pore and results in hyperpolarization of the neuron, which causes an inhibitory effect on neurotransmission.


GBLD 345 is a potent benzodiazepine receptor agonist with IC50 value of 1 nM against diazepam.

Reference:
[1].? Sieghart W. Pharmacology of benzodiazepine receptors: an update. J Psychiatry Neurosci, 1994, 19(1): 24-29.

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