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  • HX 531
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HX 531

An RXR antagonist

原价
¥537-3650
价格
430-2920
HX 531的二维码

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  • 货号: ajci17870
  • CAS: 188844-34-0
  • 别名:
  • 分子式: C29H29N3O4
  • 分子量: 483.56
  • 纯度: >98%
  • 溶解度: 0.12mg/mL in ethanol, 10mg/mL in DMSO, 15mg/mL in DMF
  • 储存: Store at -20°C
  • 库存: 现货

Background

HX 531 is an antagonist of the retinoid X receptor (RXR) with an IC50 value of 18 nM that inhibits 9-cis retinoic acid -induced transactivation of RXR.[1] It has been shown to reduce triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice on a high fat diet.[2]


Reference:
[1]. Konta, T., Xu, Q., Furusu, A., et al. Selective roles of retinoic acid receptor and retinoid x receptor in the suppression of apoptosis by all-trans-retinoic acid. J. Biol. Chem. 276(16), 12697-12701 (2001).
[2]. Yamauchi, T., Waki, H., Kamon, J., et al. Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes. J. Clin. Invest. 108(7), 1001-1013 (2001).

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