Background:
ABH ammonium salt is a strong and specific inhibitor of arginase and arginase II.
Arginase is the focal enzyme of the urea cycle catalyzing the hydrolysis of l-arginine to urea and l-ornithine. Emerging studies have identified arginase in the vasculature and have implicated this enzyme in the regulation of nitric oxide (NO) synthesis and the development of vascular disease. Upregulation of arginase inhibits endothelial NOS-mediated NO synthesis and may contribute to endothelial dysfunction in hypertension, ageing, ischaemia–reperfusion and diabetes. The induction of arginase may also promote aberrant vessel wall remodelling and neointima formation [1].
In vitro: 2(S)-amino-6-boronohexanoic acid (ABH) is inhibitor of type I arginase. At pH 7.5, ABH inhibited human type II arginase competitively with Ki value of 0.25 μM. However, at pH 9.5, ABH showed slow-binding inhibitory effects with Ki value of 8.5 nM [2].
In vivo: ABH enhanced both male and female sexual arousal responses in rabbits. In male rabbits received 150 μg ABH, the duration of the response increased by
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