A non-selective COX inhibitor
IC50: 17.4 and 13.1 μM for COX-1 and -2, respectively.
Ibufenac is a dual COX-1 and -2 inhibitor.
Cyclooxygenase (COX), also known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for formation of prostanoids, such as thromboxane and prostaglandins.
In vitro: Ibufenac was identified as an analog of the NSAID ibuprofen that could inhibit COX-1 and -2 activity with IC50 values of 17.4 and 13.1 μM, respectively [1].
In vivo: In a previous animal study, two new structural analogs, R3 and R4, along with their parent compounds, ibufenac and ibuprofen, were evaluated for their biopharmaceutical properties. Aanti-inflammatory activity was evaluated by topically administering drugs to inhibit inflammation induced by using either clove oil or arachidonic acid. Results showed that the rank order of activity was ibufenac approximately equal to ibuprofen > R3 approximately equal to R4 [2].
Clinical trial: Early clinical study found that ibufenac was a useful drug in the treatment of the symptoms of rheumatoid arthritis. Ibufenac appeared to be as effective as aspirin in this respect at the dosage levels applied and its usage was associated with considerably fewer side effects [3].
参考文献:
[1] Gülcan, H.?O.,nlü, S.,Dimoglo, A., et al. Marginally designed new profen analogues have the potential to inhibit cyclooxygenase enzymes. Arch.Pharm.Chem.Life Sci. 348, 55-61 (2015).
[2] Rao CS, Schoenwald RD, Barfknecht CF, Laban SL.? Biopharmaceutical evaluation of ibufenac, ibuprofen, and their hydroxyethoxy analogs in the rabbit eye. J Pharmacokinet Biopharm. 1992 Aug;20(4):357-88.
[3] T.? M. Chalmers. Clinical Trials of a New Drug, Ibufenac, in the Treatment of Rheumatoid Arthritis Ann Rheum Dis. 1963 Sep; 22(5): 358–362.
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