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安捷凯生物医药，安捷凯化学
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  2. Sirtuin (Sir2 proteins)
  3. BML-278
  • BML-278
BML-278的可视化放大

BML-278

An activator of SIRT1, SIRT2, and SIRT3

原价
￥537-5137
价格
￥ 430-4110
BML-278的二维码

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  • 库存: 现货
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  • 货号: ajci21058
  • CAS: 120533-76-8
  • 别名: DIETHYL1-BENZYL-4-PHENYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE锛圵S201542锛,WUXIAPPTEC"
  • 分子式: C24H25NO4
  • 分子量: 391.5
  • 纯度: >98%
  • 溶解度: DMF: 12.5 mg/ml,DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml,DMSO: 3 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 uM. It less potently activates SIRT2 and SIRT3 (EC150s = 25 and 50 uM, respectively). BML-278 induces hypoacetylation on α-tubulin in U937 cells that are pretreated with SAHA , a histone deacetylase inhibitor. It arrests cell cycling at the G1/S phase, reduces senescence in primary human mesenchymal cells, and significantly increases mitochondrial density in murine C2C12 myoblasts.

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