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安捷凯生物医药，安捷凯化学
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  2. Cyclooxygenase (COX)
  3. CAY10589
  • CAY10589
CAY10589的可视化放大

CAY10589

Dual Inhibitor of mPGES-1 and 5-LO

原价
￥925-7087
价格
￥ 740-5670
CAY10589的二维码

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  • 库存: 现货
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  • 货号: ajci21618
  • CAS: 1077626-52-8
  • 别名:
  • 分子式: C25H28ClN3O2S
  • 分子量: 470
  • 纯度: >98%
  • 溶解度: DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml,Ethanol: 10 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Microsomal Prostaglandin E2 Synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE2, which is directly involved in signaling during inflammation, fever and pain. 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs), which are pro-inflammatory mediators. CAY10589 is a dual inhibitor of mPGES-1 (IC50 = 1.3 μM) and 5-LO (IC50 = 1.0 μM). It effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays. CAY10589 has minor effects on COX-1 and COX-2, inhibiting these enzymes 34% and 38.8%, respectively, at 10 μM.

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