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安捷凯生物医药，安捷凯化学
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  2. Na+/K+-ATPase
  3. Hellebrin
  • Hellebrin
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Hellebrin

An Na+/K+-ATPase inhibitor

原价
￥962-4000
价格
￥ 770-3200
Hellebrin的二维码

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  • 库存: 现货
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  • 货号: ajci21644
  • CAS: 13289-18-4
  • 别名: 蒜蘆黎素
  • 分子式: C36H52O15
  • 分子量: 724.8
  • 纯度: >98%
  • 溶解度: Water: 4 mg/ml
  • 储存: Store at -20°C, protect from light
  • 库存: 现货

Background

Hellebrin is a cardiac glycoside that potently inhibits the Na+/K+-ATPase by binding to it and blocking its non-canonical function as a receptor for cardiac glycosides. Hellebrin has a higher affinity for the α1β1 subunit of the Na+/K+-ATPase than the α2β1 or α3β1 complexes, in contrast to other cardiac glycosides. This affinity for the α1β1 complex correlates with its cancer cell growth inhibition (GI50 = 6-58 nM in various human cancer cell lines). Hellebrin also induces caspase-dependent apoptosis in Jurkat T cells.

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