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  2. PKC (Protein kinase C)
  3. Bisindolylmaleimide XI (hydrochloride)
  • Bisindolylmaleimide XI (hydrochloride)
Bisindolylmaleimide XI (hydrochloride)的可视化放大

Bisindolylmaleimide XI (hydrochloride)

A PKC inhibitor

原价
￥1450-6012
价格
￥ 1160-4810
Bisindolylmaleimide XI (hydrochloride)的二维码

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  • 库存: 现货
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  • 货号: ajci21674
  • CAS: 145333-02-4
  • 别名: Ro 32-0432; Ro 31-8830 hydrochloride
  • 分子式: C28H28N4O2.HCl
  • 分子量: 489
  • 纯度: >98%
  • 溶解度: DMSO: Soluble,Methanol: Soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

Bisindolylmaleimide XI (BIM XI) is a selective, cell-permeable protein kinase C (PKC) inhibitor that displays 10-fold greater selectivity for PKCα (IC50 = 9 nM) and 4-fold greater selectivity for PKCβI (IC50 = 28 nM) over Ca2+-independent PKCε (IC50 = 108 nM). Inhibition of PKCα by BIM XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure. BIM XI prevents T-cell activation and proliferation (with IC50s ranging from 30-150 nM) associated with chronic inflammatory responses in vivo.

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