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  • CAY10654
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CAY10654

Immunosuppressive homoserine lactone analog

原价
¥500-8312
价格
400-6650
CAY10654的二维码

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  • 货号: ajci22062
  • CAS: 1298023-69-4
  • 别名:
  • 分子式: C17H25ClN2O3
  • 分子量: 340.9
  • 纯度: >98%
  • 溶解度: DMF: 20 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

The gram-negative pathogen Pseudomonas aeruginosa uses N-acylated-L-homoserine lactones (AHLs) in quorum sensing to modulate transcriptional activators, including LasR, and regulate the expression of virulence factors. The same AHLs suppress the host immune system. CAY10654 is a synthetic analog of natural AHLs that suppresses host immunity without inducing LasR. It inhibits the proliferation of mouse peripheral blood leukocytes by concanavalin A (EC50 = 9.3 μM) without concurrent cytotoxicity. LasR is not induced by 100 μM CAY10654, although LasR is potently induced by natural AHL (5 μM) in positive control experiments.

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