现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • TMB 8 (hydrochloride)
TMB 8 (hydrochloride)的可视化放大

TMB 8 (hydrochloride)

A non-competitive antagonist of nAChRs and an inhibitor of intracellular calcium availability

原价
¥462-837
价格
370-670
TMB 8 (hydrochloride)的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajci23118
  • CAS: 53464-72-5
  • 别名: 3,4,5-三甲氧基苯甲酸(8-二乙氨基正辛基)酯盐酸盐
  • 分子式: C22H37NO5 ? HCl
  • 分子量: 432
  • 纯度: >98%
  • 溶解度: Chloroform: Slightly Soluble,Methanol: Slightly Soluble,Water: Slightly Soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

TMB 8 is a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) with IC50 values of 390 and 350 nM, respectively, for human muscle-type and α3β4 subunit-containing ganglionic nAChRs expressed in TE671/RD or SH-SY5Y cells. It inhibits nicotine-induced dopamine release from rat brain synaptosomes (IC50 = 480 nM). TMB 8 also reduces calcium availability in smooth and skeletal muscle, blocking the contractile response in isolated rabbit aortic strip when used at a concentration of 50 µM and inhibiting calcium influx and efflux in isolated guinea pig ileum when used at a concentration of 65 µM. It has been used in the study of intracellular calcium dynamics, particularly in smooth muscle. TMB 8 also inhibits protein kinase C (PKC) activity in a dose-dependent manner.

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服