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安捷凯生物医药，安捷凯化学
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  2. Angiotensin Receptor
  3. Dihydrotetrabenazine
  • Dihydrotetrabenazine
Dihydrotetrabenazine的可视化放大

Dihydrotetrabenazine

An active metabolite of tetrabenazine

原价
￥2037-3862
价格
￥ 1630-3090
Dihydrotetrabenazine的二维码

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  • 库存: 现货
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  • 货号: ajci64528
  • CAS: 3466-75-9
  • 别名: 反式(2,3)-二氢丁苯那嗪
  • 分子式: C19H29NO3
  • 分子量: 319.4
  • 纯度: >98%
  • 溶解度: Chloroform: soluble,Methanol: soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

Dihydrotetrabenazine is an active metabolite of the vesicular monoamine transporter 2 (VMAT2) inhibitor tetrabenazine that is generated by hepatic carbonyl reductases. Dihydrotetrabenazine binds to mouse pons medulla, hypothalamus, and striatum (Kds = 2.72, 2.28, and 2.4 nM, respectively) and inhibits synaptic vesicular serotonin (5-HT) uptake (IC50s = 2.2, 2.8, and 2.3 nM, respectively). It also binds to human caudate nucleus, hippocampus, and substantia nigra pars compacta (Kds = 2.9, 2.5, and 2.8 nM, respectively). Dihydrotetrabenazine stereoisomers bind to VMAT2 in rat striatum.

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