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  • (±)13-HpODE
(±)13-HpODE的可视化放大

(±)13-HpODE

Hydroperoxide mixture derived from linoleic acid

原价
¥1575-17000
价格
1260-13600
(±)13-HpODE的二维码

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  • 货号: ajci64952
  • CAS: 23017-93-8
  • 别名: 13-Hydroperoxylinoleic acid; Linoleic acid 13-hydroperoxide
  • 分子式: C18H32O4
  • 分子量: 312.4
  • 纯度: >98%
  • 溶解度: 50 mg/ml in DMF, 50 mg/ml in DMSO, 50 mg/ml in ethanol
  • 储存: Store at -20°C
  • 库存: 现货

Background

(±)13-HpODE is a racemic mixture of hydroperoxides derived non-enzymatically from linoleic acid through the action of reactive oxygen species. Lipid hydroperoxides, including 13-HpODE, have limited direct biological actions, such as the activation of lipoxygenases. [1] Normally, (±)13-HpODE is rapidly reduced to (±)13-HODE, a compound which exhibits many biological activities. [2] Importantly, 13-HpODE can also be metabolized to unsaturated aldehydes that can, in turn, covalently bind to DNA, amino acids, and proteins.[3][4][5]


Reference:
[1]. Jones, G.D., Russell, L., Darley-Usmar, V.M., et al. Role of lipid hydroperoxides in the activation of 15-lipoxygenase. Biochemistry 35, 7197-7203 (1996).
[2]. Kühn, H. Biosynthesis, metabolization and biological importance of the primary 15-lipoxygenase metabolites 15-hydro(pero)xy-5Z,8Z,11Z,13E-eicosatetraenoic acid and 13-hydro(pero)xy-9Z,11E-octadecadienoic acid. Progress in Lipid Research 35, 203-226 (1996).
[3]. Williams, M.V., Wishnok, J.S., and Tannenbaum, S.R. Covalent adducts arising from the decomposition products lipid hydroperoxides in the presence of cytochrome C. Chemical Research in Toxicology 20(5), 767-775 (2007).
[4]. Iwahashi, H., Nishizaki, K., and Takagi, I. Cytochrome c catalyzes the formation of pentyl radical and octanoic acid radical from linoleic acid hydroperoxide. Biochemistry Journal 361, 57-66 (2002).
[5]. Kawai, Y., Kato, Y., Fujii, H., et al. Immunochemical detection of a novel lysine adduct using an antibody to linoleic acid hydroperoxide-modifies protein. Journal of Lipid Research 44, 1124-1131 (2003).

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