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Background:
JWH 018 (1-pentyl-3-(1-naphthoyl)indole) is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 9.0 and 2.94 nM, respectively). This cannabimimetic compound has frequently been found in herbal blends. JWH 018 2’-naphthyl-N-(2,2-dimethylpropyl) isomer differs structurally from JWH 018 by having the naphthyl group attached at the 2’ position and 2,2-dimethylpropyl in place of the pentyl chain. The biological activities of this compound have not been characterized.
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