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  2. RIP kinase
  3. CAY10575
  • CAY10575
CAY10575的可视化放大

CAY10575

An IKKβ and Plk1 inhibitor

原价
￥600-9662
价格
￥ 480-7730
CAY10575的二维码

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  • 库存: 现货
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  • 货号: ajci70594
  • CAS: 916985-21-2
  • 别名: IKK2 Inhibitor 3, Polo-like Kinase Inhibitor 1
  • 分子式: C22H21N3O6S2
  • 分子量: 487.6
  • 纯度: >98%
  • 溶解度: DMF: 1mg/mL,DMSO: 10mg/mL,DMSO:PBS(7.2pH) 1:4: 0.2mg/mL
  • 储存: Store at -20°C
  • 库存: 现货

Background

The NF-κB/Rel transcription factors, known to be involved in the regulation of pro-inflammatory cytokines and the pathogenesis of a variety of diseases, are present in the cytosol in an inactive state, complexed with inhibitory IκB proteins. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. IKK-ε, a homolog of IKK-α and IKK-β, can also activate NF-κB. IKK-ε is expressed predominantly in immune cells and is thought to play a role in the immune response. CAY10575 is a benzimidazole analog that inhibits IKK-ε with an IC50 value of ~15.8 µM.

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