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  • Irindalone (Lu 21-098)
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Irindalone (Lu 21-098)

Irindalone (Lu 21-098) 是一种新型血清素 5-HT2 拮抗剂。

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¥8350-49587
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6680-39670
Irindalone (Lu 21-098)的二维码

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  • 货号: ajce46270
  • CAS: 96478-43-2
  • 别名: 茚达酮,Lu 21-?098
  • 分子式: C24H29FN4O
  • 分子量: 408.51
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

Irindalone is a novel serotonin 5-HT2 antagonist.


Irindalone causes a concentration-related inhibition of serotonin-induced contractions and shifts the serotonin curve to the right. Irindalone is more potent in inhibiting the serotonin-induced contractions. Irindalone has a similar profile in vitro, with a high affinity for serotonin 5-HT2 receptors and about a 10 times lower affinity for α1-adrenoceptors[1].


Irindalone dose dependently lowers the blood pressure in spontaneously hypertensive rats (SHR) and renal hypertensive dogs[1].


[1]. Mikkelsen EO, et al. Comparison of the effect of irindalone, a novel serotonin 5-HT2 antagonist and ketanserin on mechanical responses of rat thoracic aorta. Eur J Pharmacol. 1988 Apr 27;149(1-2):145-8.

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