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Imirestat (AL 1576) (AL 1576) 是一种醛糖还原酶抑制剂,用于治疗糖尿病。
Imirestat (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes.
Imirestat (1 mg/kg) improves nerve conduction velocity but is without effect upon the resistance to hypoxic conduction blockade or the deficit in insulin-stimulated oubain-sensitive ATPase activity[1].
[1]. Carrington AL, et al. Aldose reductase inhibition with imirestat-effects on impulse conduction and insulin-stimulation of Na+/K(+)-adenosine triphosphatase activity in sciatic nerves of streptozotocin-diabetic rats. Diabetologia. 1991 Jun;34(6):397-401.
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