An antimicrobial peptide
Histatin 5 is a salivary antimicrobial peptide.1,2,3 It is active against C. albicans (LC50 = 1.8 ?M), as well as A. baumannii, P. aeruginosa, and E. cloacae (MICs = 38, 47, and 90 ?M, respectively).1,2 Topical application of histatin 5 (20 ?M) decreases fungal burden in a mouse model of C. albicans-induced vulvovaginal candidiasis.3
1.Edgerton, M., Koshlukova, S.E., Lo, T.E., et al.Candidacidal activity of salivary histatinsJ. Biol. Chem.273(32)20438-20447(1998) 2.Du, H., Puri, S., McCall, A., et al.Human salivary protein histatin 5 has potent bactericidal activity against ESKAPE pathogensFront. Cell. Infect. Microbiol.741(2017) 3.Liao, H., Liu, S., Wang, H., et al.Efficacy of Histatin5 in a murine model of vulvovaginal candidiasis caused by Candida albicansPathog. Dis.75(6)(2017)
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