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  • COX-2-IN-1
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COX-2-IN-1

COX-2-IN-1是一个强效的COX-2抑制剂,其IC50值为3.9μM。

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¥3225-19062
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2580-15250
COX-2-IN-1的二维码

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  • 货号: ajce48166
  • CAS: 787623-48-7
  • 别名:
  • 分子式: C18H14ClF3N4O2S
  • 分子量: 442.84
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

COX-2-IN-1 is potent and slective COX-2 inhibitor with an IC50 of 3.9 μM.


COX-2-IN-1(compound 5f) is an inhibitor of COX-1 and COX-2 with IC50s of >100 and 3.9 μM, respctively. Comparison of 5b and COX-2-IN-1 shows that smaller halogen atom at 5th position on the indole ring enhances COX-2 enzyme inhibition activity, whereas the presence of a larger bromine atom at 6th position of the ring improves the inhibitory activity (5d, 5e and 5h) of the compound[1].


[1]. Reddy MV, et al. Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors. Bioorg Med Chem. 2008 Apr 1;16(7):3907-16.

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