A COX inhibitor and an antiplatelet agent
Pamicogrel is a COX inhibitor and an antiplatelet agent.1,2,3 It inhibits platelet aggregation induced by arachidonic acid or collagen in washed isolated rabbit platelets (IC50s = 1.5 and 0.43 ?M, respectively).2 Pamicogrel (1 mg/kg) reduces thrombus weight in a guinea pig model of arteriovenous shunt thrombosis.3
1.Light, P.Pamicogrel (Kanebo)IDrugs2(9)938-942(1999) 2.Yokota, K., Yamamoto, N., Morimoto, Y., et al.Effect of KBT-3022, a new diphenylthiazole derivative, on platelet functionsJ. Pharm. Pharmacol.47(9)768-774(1995) 3.Yokota, K., Yamashita, A., and Oda, M.Anti-thrombotic activity of KBT-3022 in experimental models of thrombosisJpn. J. Pharmacol.68(2)201-206(1995)
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