Bendazol (2-Benzylbenzimidazole, Dibazol, Dibazole, Bendazole, Tromasedan) is a hypotensive drug that enhances NO synthase activity in renal glomeruli and collecting tubules. Bendazol inhibits the progression of form-deprivation myopia (FDM) and suppresse
Bendazol (2-Benzylbenzimidazole, Dibazol, Dibazole, Bendazole, Tromasedan) is a hypotensive drug that enhances NO synthase activity in renal glomeruli and collecting tubules. Bendazol inhibits the progression of form-deprivation myopia (FDM) and suppresses the upregulation of HIF-1α.
Bendazol enhances NO synthase activity in renal glomeruli and collecting tubules, but this effect is less pronounced and short lasting. During the first week after injection of bendazol, insignificant elevation of NO synthase activity is observed in the proximal nephron segments.[1]
[1] E V Eliseeva, et al. Bull Exp Biol Med. 2017 Jan;162(3):357-361. [2] Liyang Tong, et al. Ophthalmic Physiol Opt. 2020 Sep;40(5):567-576.
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