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GSK-843是一种受体相互作用蛋白激酶3(RIP3orRIPK3)抑制剂,高亲和力结合RIP3激酶结构域,IC50值为8.6nM,并抑制激酶活性,IC50值为6.5nM。
GSK-843 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM[1]. IC50: 6.5 nM (RIP3)[1]
[1]. Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56(4):481-95.
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