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  • 4-O-Methyl honokiol
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4-O-Methyl honokiol

A phenol with diverse biological activities

原价
¥1625-2612
价格
1300-2090
4-O-Methyl honokiol的二维码

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  • 货号: ajce54528
  • CAS: 68592-15-4
  • 别名: 4--O-甲基和厚朴酚
  • 分子式: C19H20O2
  • 分子量: 280.36
  • 纯度: >98%
  • 溶解度: DMF: 33 mg/ml,DMSO: 33 mg/ml,Ethanol: 33 mg/ml,Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

4'-O-Methylhonokiol is a phenol that has been found in M. grandiflora and has diverse biological activities.1,2,3,4 It is active against the bacteria B. subtilis, S. aureus, and M. smegmatis (MIC = 2.5 ?g/ml for all) and the fungus T. mentagrophytes (MIC = 1.25 ?g/ml).1 4'-O-Methylhonokiol (10 and 30 ?M) inhibits LPS-induced activation of NF-kB and production of nitric oxide (NO) in RAW 264.7 macrophages.2 In vivo, 4'-O-Methylhonokiol (20 and 200 mg/kg) reduces carrageenan-induced paw edema in mice. It reduces neuronal apoptosis and escape latency in the Morris water maze in a mouse model of Alzheimer's disease induced by amyloid-β 1-42 (Aβ42) when administered at a dose of 1 mg/kg.3 4-O-methylhonokiol also reduces plasma cholesterol and triglyceride levels, ameliorates hepatic steatosis, and improves insulin resistance in a mouse model of high-fat diet-induced obesity.4


1.Clark, A.M., El-Feraly, F.S., and Li, W.S.Antimicrobial activity of phenolic constituents of Magnolia grandiflora LJ. Pharm. Sci.70(8)951-952(1981) 2.Zhou, H.Y., Shin, E.M., Guo, L.Y., et al.Anti-inflammatory activity of 4-methoxyhonokiol is a function of the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB, JNK and p38 MAPK inactivationEur. J. Pharmacol.586(1-3)340-349(2008) 3.Lee, J.W., Lee, Y.K., Lee, B.J., et al.Inhibitory effect of ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on memory impairment and neuronal toxicity induced by beta-amyloidPharmacol. Biochem. Behav.95(1)31-40(2010) 4.Zhang, Z., Chen, J., Jiang, X., et al.The magnolia bioactive constituent 4-O-methylhonokiol protects against high-fat diet-induced obesity and systemic insulin resistance in miceOxid. Med. Cell. Longev.2014965954(2014)

Protocol

Cell experiment:

Cells (5 × 104 cells per well) are plated onto 24-well plates. The cell growth inhibitory effect of 4-O-Methyl honokiol is evaluated in cells treated with 4-O-Methyl honokiol (0-30 μM) for 0-72 h, using an excluded trypan blue assay[1].

Animal experiment:

Six-week-old male BALB/c athymic nude mice are used in the assay. SW620 and PC3 cells are injected s.c. (1 × 107 cells in 0.1 mL PBS per animal) into the lower right flanks of mice. After 20 days, when the tumours have reached an average volume of 300-400 mm3 or about 50 mm3, the tumour-bearing nude mice are i.p. injected with 4-O-Methyl honokiol (40 and 80 mg/kg dissolved in 0.1% DMSO) twice per week for 3 weeks. Cisplatin (10 mg/kg) is also i.p. injected once a week as a positive control. The group treated with 0.1% DMSO is designated as the control. The tumour volumes are measured with vernier calipers and calculated by the following formula: (A × B2)/2, where A is the larger and B is the smaller of the two dimensions[1].

参考文献:

[1]. Lee NJ, et al. 4-O-methylhonokiol, a PPARγ agonist, inhibits prostate tumour growth: p21-mediated suppression of NF-κB activity. Br J Pharmacol. 2013 Mar;168(5):1133-45.
[2]. Lee YJ, et al. Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models. J Neuroinflammation. 2012 Feb 19;9:35.

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