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Abemaciclib Metabolites M2 (LSN2839567) 是 Abemaciclib 的代谢物,是一种有效的 CDK4 和 CDK6 抑制剂,IC50 分别为 1.2 和 1.3 nM。抗癌活性。
Abemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity[1]. CDK4|1-3 nM (IC50)|CDK6|1-3 nM (IC50)
[1]. Teresa Burke, et al. Abstract 2830: The major human metabolites of abemaciclib are inhibitors of CDK4 and CDK6. Cancer Research. July 2016, 76 (14).
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