An anthroquinone with diverse biological activities
Aloin is a mixture of aloin A and aloin B , anthraquinones found in Aloe vera, and has diverse biological activities.1,2,3 It reduces IL-6 and TNF-α expression as well as nitric oxide (NO) production and COX-2 and inducible NO synthase (iNOS) expression in LPS-stimulated RAW 264.7 cells when used at concentrations ranging from 100 to 400 mM.1 Aloin inhibits LPS-induced p65 acetylation, nuclear translocation of NF-kB, and apoptosis in RAW 264.7 cells. It reduces motility of T. congolense in vitro and reduces the number of parasites in T. congolense-infected mice when administered at a dose of 400 mg/kg.2 Aloin (50 and 100 mg/kg) also reduces activity of glutathione peroxidase (GPX), glutathione-S-transferase (GST), and glutathione reductase (GR), the level of colonic malondialdehyde (MDA), and the number of aberrant crypt foci and mucin-depleted foci in a rat model of 1,2-dimethylhydrazine-induced colon cancer.3
1.Luo, X., Zhang, H., Wei, X., et al.Aloin suppresses lipopolysaccharide-induced inflammatory response and apoptosis by inhibiting the activation of NF-κBMolecules23(3)E517(2018) 2.Tewabe, Y., Bisrat, D., Terefe, G., et al.Antitrypanosomal activity of aloin and its derivatives against Trypanosoma congolense field isolateBMC Vet. Res.1061(2014) 3.Hamiza, O.O., Rehman, M.U., Khan, R., et al.Chemopreventive effects of aloin against 1,2-dimethylhydrazine-induced preneoplastic lesions in the colon of Wistar ratsHum. Exp. Toxicol.33(2)148-163(2014)
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