JHU-083 (Ethyl 2-(2-Amino-4-methylpentanamido)-DON) is a novel prodrug of DON.JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.Solutions are best fre
JHU-083 (Ethyl 2-(2-Amino-4-methylpentanamido)-DON) is a novel prodrug of DON.JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.Solutions are best fresh-prepared.
JHU-083 selectively inhibits T-cell proliferation and decreases T-cell activation, with no e?ect on DCs.[2]
In vivo, orally administered JHU-083 significantly decreases the experimental autoimmune encephalomyelitis(EAE) severity in both prevention and treatment paradigms and reverses EAE-induced cognitive impairment.[2]
[1] Zhu X,et al.Neuropsychopharmacology.2019;44(4):683-694 [2] Hollinger KR,et al.Neurol Neuroimmunol Neuroinflamm.2019 29;6(6)
动态评分
0.0