A flavone with diverse biological activities
Luteolin 7-O-glucuronide is a flavonoid that has been found in S. chloroleuca and A. pilosa, and has diverse biological activities, including antioxidant, enzyme inhibitory, and anti-inflammatory properties.1,2,3 It scavenges DPPH radicals in a cell-free assay (IC50 = 80.6 μM).1 Luteolin 7-O-Glucuronide inhibits porcine α-amylase and yeast α-glucosidase in vitro (IC50s = 61.5 and 14.7 μM, respectively).3 It also inhibits rat aldose reductase in vitro (IC50 = 0.7 μM) and sorbitol accumulation in isolated rat lens by 91.8% when used at a concentration of 5 μg/ml.1 Luteolin 7-O-glucuronide inhibits LPS-induced cytokine release from RAW 264.7 macrophages in a dose-dependent manner.2
1.Kim, S.B., Hwang, S.H., Suh, H.-W., et al.Phytochemical analysis of Agrimonia pilosa Ledeb, its antioxidant activity and aldose reductase inhibitory potentialInt. J. Mol. Sci.18(2)379(2017) 2.Cho, Y.-C., Park, J., and Cho, S.Anti-inflammatory and anti-oxidative effects of luteolin-7-O-glucuronide in LPS-stimulated murine macrophages through TAK1 inhibition and Nrf2 activationInt. J. Mol. Sci.21(6)2007(2020) 3.Asghari, B., Salehi, P., Sonboli, A., et al.Flavonoids from Salvia chloroleuca with α-amylsae and α-glucosidase inhibitory effectIran. J. Pharm. Res.14(2)609-615(2015)
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